Cryptic promoters in yeast drive alternative protein isoforms

Great to see our new paper finally out in Genome Research describing how many cryptic promoters drive in fact the expression of alternative proteins.

Here the link to our paper in Genome Research: Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast. Wei W, Hennig BP, Wang J, Zhang Y, Ilaria Piazza, Pareja Sanchez Y, Chabbert CD, Adjalley SH, Steinmetz LM, Pelechano V. Genome Res. 2019 Nov 18. doi:10.1101/gr.243378.118

And you can also check our preprint in BioRxiv.

We combine yeast genetics with omic approaches from the nucleus to the cytoplasm (BAR-seq, 5’cap sequencing, TIF-Seq 5PSeq and proteomic analysis). Great collaboration with my colleague Wei Wu and my former mentor Lars Steinmetz, and many former good colleagues from EMBL.