In a recent work we showed that cellular RNA is massively degraded upon Sindbis virus infection, and this appears to apply to a broad range of cytopathic viruses. The goal of this project is to understand how cellular RNA degradation is triggered and what its consequences in infection are. We will focus on the exonuclease XRN1 that is stimulated upon the infection of several RNA viruses.
This project is a join effort between the Castello lab and thePelechano’s lab and combines cutting edge transcriptomic approaches with virology methods and computational biology. The student will be mainly based at the University of Glasgow, at the MRC Center for Virus Research.
If you are interested, you can apply to this project here: https://www.gla.ac.uk/colleges/mvls/graduateschool/mrcdtpprecisionmedicine/