Really happy to see Yujie’s work on how ribosomes sense nutrition leading to massive frameshift and mRNA decay published now.
If you want to learn a bit more on how we found this new mechanism, please have a look to our manuscript.
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay. Zhang, Y., Nersisyan, L., Fürst, E., Alexopoulos, I., Santolaria, C., Huch, S., Bassot, C., Garre, E., Sunnerhagen, P., Piazza, I., Pelechano, V., 2025. Mol. Cell 85, 2017-2031.e7.